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Nine months after 12-day war, US, Israel seek to topple Iran’s leaders

The United States and Israel are pursuing a coordinated strategy aimed at dismantling Iran’s leadership, a significant escalation nearly nine months after a 12-day conflict that both nations declared a strategic victory. This renewed push for regime change in Tehran comes amidst ongoing, albeit fragile, nuclear negotiations and threatens to further destabilize an already volatile Middle East. The current offensive, launched on Saturday, encompasses a multifaceted approach targeting Iranian officials, military infrastructure, and its nuclear program.

The renewed pressure on Iran’s leadership follows a period of intense diplomatic activity and military posturing. Israeli Prime Minister Benjamin Netanyahu, who declared in June of last year that Israeli attacks had sent Tehran’s nuclear program "to oblivion," is now a key architect of this intensified campaign. The current offensive is seen by analysts as a direct continuation of Israel’s long-standing objective to prevent Iran from acquiring nuclear weapons, a stance that has historically shaped Netanyahu’s foreign policy.

This latest offensive unfolds as indirect negotiations between the U.S. and Iran, mediated by Oman, were reportedly making "significant progress" on Iran’s nuclear program. Foreign Minister Badr bin Hamad Albusaidi of Oman announced on Thursday, at the conclusion of the third round of talks in Geneva, that technical discussions were expected to resume on Monday. Reports indicated Iran had agreed to cease enriching uranium stockpiles and allow for full International Atomic Energy Agency (IAEA) verification, a move intended to make the development of nuclear weapons impossible.

However, the efficacy and long-term implications of these diplomatic overtures are now cast in doubt by the simultaneous military actions. Tehran, a signatory to the Nuclear Non-Proliferation Treaty, has consistently maintained that its nuclear program is for peaceful, civilian purposes and has no intention of developing atomic weapons. This assertion has been met with skepticism by both Washington and Jerusalem, who view Iran’s advancements as an existential threat.

Precedents and Escalation

The current campaign is not an isolated event but rather an intensification of a protracted geopolitical struggle. Netanyahu has long advocated for military intervention to neutralize Iran’s nuclear capabilities. His opposition to the 2015 Joint Comprehensive Plan of Action (JCPOA), negotiated under the Obama administration, was vocal and unwavering. He viewed the deal, which imposed curbs on Iran’s nuclear program in exchange for sanctions relief, as insufficient to address the perceived threat.

The withdrawal of the United States from the JCPOA in 2018 under President Donald Trump, who characterized the deal as "horrible," ushered in an era of "maximum pressure" sanctions. This policy aimed to force Iran back to the negotiating table for a revised agreement. Netanyahu saw an opportune moment to advance his agenda following Trump’s subsequent electoral success.

Following the October 7, 2023, raid on Israel and the subsequent Israeli military operation in Gaza, Netanyahu, reportedly with a "green light" from the United States, launched an initial assault on Iran on June 13, 2025. The U.S. participated briefly in this operation, targeting several Iranian nuclear facilities. Despite Trump’s pronouncements that these strikes had crippled Iran’s nuclear capabilities, he also pushed for the complete dismantling of the program, a demand Tehran has consistently rejected.

Strategic Objectives and Military Buildup

U.S. officials have confirmed that Saturday’s strikes targeted Iranian officials, missile storage and launching sites, and nuclear facilities. Iranian state media reported attacks on key government and military installations, including the Ministry of Intelligence, the Ministry of Defence, the Atomic Energy Organisation of Iran, and the Parchin military complex.

In response, Iran retaliated with strikes against Israel and bases utilized by the U.S. military throughout the Gulf region, including in Bahrain, Qatar, Kuwait, and the United Arab Emirates. This tit-for-tat exchange highlights the interconnectedness of the regional security landscape and the potential for rapid escalation.

The United States has significantly bolstered its military presence in the region, amassing its largest military arsenal since the 2003 invasion of Iraq. This includes the deployment of the USS Gerald R. Ford, the world’s largest aircraft carrier, underscoring the seriousness of the current posture.

Shifting Demands and Regional Alliances

Beyond the nuclear issue, U.S. and Israeli officials have articulated broader strategic objectives. Analysts suggest that while the U.S. has primarily focused on preventing Iran from obtaining nuclear weapons, Netanyahu has also pressed for Iran to negotiate its missile capabilities. A key demand reportedly includes limiting the range of Iranian missiles to a "300-kilometer (185-mile) red line."

Furthermore, Netanyahu has sought U.S. support in compelling Tehran to cease its backing of regional proxy allies. These include groups such as Hamas, Hezbollah, and the Houthis, whose activities are seen by Israel and its allies as destabilizing forces in the Middle East.

While Israel claimed a strategic victory in the 12-day war last June, Iranian missile attacks inflicted substantial damage on Israeli cities. Official reports indicated that up to 33 people were killed in these attacks, contrasted with over 600 Iranians killed and more than 3,000 hospitalized. This disparity in casualties underscores the asymmetric nature of the conflict and the significant defensive capabilities of both sides.

The Path Forward: Uncertainty and Risk

The current confrontation presents a complex and uncertain future for the Middle East. While Iran’s military capabilities do not rival those of the United States and Israel, predicting the ultimate outcome of this escalating conflict remains challenging.

U.S. officials have expressed caution regarding the potential for entanglement in a prolonged Middle Eastern conflict, drawing parallels to the protracted and costly 2003 invasion of Iraq, a war that Trump had previously condemned as a "disastrous mistake." Conversely, Iranian officials have warned that the U.S. would face a debilitating quagmire should it engage in direct military action.

Recent reports from The Washington Post have indicated that Chairman of the Joint Chiefs of Staff General Dan Caine has briefed leadership on the potential risks of attacking Iran, including the possibility of becoming mired in a protracted conflict and facing U.S. casualties.

However, there are also signals of a more confident stance within the U.S. administration. Vice President JD Vance was quoted by The Washington Post on Thursday stating there is "no chance" that U.S. strikes on Iran would lead to the United States becoming involved in a years-long, drawn-out war. Vance emphasized his belief that such a scenario is highly improbable, asserting, "The idea that we’re going to be in a Middle Eastern war for years with no end in sight – there is no chance that will happen." This assertion suggests a belief within certain circles of the U.S. government that any military engagement would be swift and decisive, avoiding the pitfalls of past interventions.

The interplay between diplomatic efforts aimed at de-escalation and military actions intended to exert pressure creates a precarious balance. The coming weeks and months will be critical in determining whether these concurrent strategies lead to a verifiable de-escalation of tensions or propel the region further into a cycle of conflict and instability. The broader implications for global energy markets, regional alliances, and the long-term security architecture of the Middle East remain significant concerns for international observers and policymakers alike.

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